Sleep Disorders

Key Research Findings

Cannabis, pain, and sleep: lessons from therapeutic clinical trials of Sativex®, a cannabis‐based medicine. (2007)
  • “Experience to date with Sativex in numerous Phase I – III studies in 2000 subjects with 1000 patient years of exposure demonstrate marked improvement in subjective sleep parameters in patients with a wide variety of pain conditions including multiple sclerosis, peripheral neuropathic pain, intractable cancer pain, and rheumatoid arthritis, with an acceptable adverse event profile.”
  • “No tolerance to the benefit of Sativex on pain or sleep, nor need for dosage increases have been noted in safety extension studies of up to four years, wherein 40– 50% of subjects attained good or very good sleep quality, a key source of disability in chronic pain syndromes that may contribute to patients quality of life.”
Cannabis, cannabinoids, and sleep: a review of the literature. (2017)
  • “Initial work examining specific cannabinoids suggests a potential therapeutic effect of high-dose CBD and low-dose THC for sleep.
  • ECS is a critical system involved in the regulation of the circadian rhythm sleep–wake cycle, highlighting the importance of examining the impact of cannabinoids on sleep. The role of the ECS on circadian rhythms has been further supported by work demonstrating that a lack of normal sleep causes dysregulation within the ECS, while elevation in the ECS at the receptor level is involved in the homeostatic recovery of sleep after non-normal sleep.”
  • “CBD may hold promise for REM sleep behavior disorder and excessive daytime sleepiness…”
Hypnotic and antiepileptic effects of cannabidiol. (1981)
  • Low-dose CBD has a stimulating effect, while high-dose CBD has a sedating effect.
  • In individuals with insomnia, results suggested that administration of 160 mg/day of CBD increased total sleep time and decreased the frequency of arousals during the night, while low-dose CBD has been associated with increased wakefulness
Effect of cannabidiol on sleep disruption induced by the repeated combination tests consisting of open field and elevated plus-maze in rats. (2012)
  • CBD efficiently blocked anxiety-induced REM sleep suppression, but had little effect on the alteration of NREM sleep. Conclusively, CBD may block anxiety-induced REM sleep alteration via its anxiolytic effect, rather than via sleep regulation per se.”
Cannabis and Insomnia (2011)
  • “Among those who had reported trouble sleeping, 79% reported increased sleep quality after using cannabis.”
  • “Both those with sleep difficulties and those without reported a significant decrease in time to sleep after the use of cannabis. This suggests cannabis may be an effective treatment for insomnia.”
Effectiveness of cannabidiol oil for pediatric anxiety and insomnia as part of posttraumatic stress disorder: a case report. (2016)
  • “This case study provides clinical data that support the use of cannabidiol [CBD] oil as a safe treatment for reducing anxiety and improving sleep in a young girl with posttraumatic stress disorder.”
The use of a synthetic cannabinoid in the management of treatment-resistant nightmares in posttraumatic stress disorder (PTSD). (2009)
  • The authors of this study found that treatment with nabilone produced a reduction in nightmare presence and intensity and increased participants’ hours of sleep per night.
Preliminary, Open-Label, Pilot Study of Add-On Oral D9 -Tetrahydrocannabinol in Chronic Post-Traumatic Stress Disorder (2014)
  • “The results show good tolerance and safety, reduction of PTSD hyperarousal symptoms, improved sleep quality and reduced frequency of nightmares.”

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