“Experience to date with Sativex in numerous Phase I – III studies in 2000 subjects with 1000 patient years of exposure demonstrate marked improvement in subjective sleep parameters in patients with a wide variety of pain conditions including multiple sclerosis, peripheral neuropathic pain, intractable cancer pain, and rheumatoid arthritis, with an acceptable adverse event profile.”
“No tolerance to the benefit of Sativex on pain or sleep, nor need for dosage increases have been noted in safety extension studies of up to four years, wherein 40– 50% of subjects attained good or very good sleep quality, a key source of disability in chronic pain syndromes that may contribute to patients quality of life.”
“Initial work examining specific cannabinoids suggests a potential therapeutic effect of high-dose CBD and low-dose THC for sleep.“
“ECS is a critical system involved in the regulation of the circadian rhythm sleep–wake cycle, highlighting the importance of examining the impact of cannabinoids on sleep. The role of the ECS on circadian rhythms has been further supported by work demonstrating that a lack of normal sleep causes dysregulation within the ECS, while elevation in the ECS at the receptor level is involved in the homeostatic recovery of sleep after non-normal sleep.”
“CBD may hold promise for REM sleep behavior disorder and excessive daytime sleepiness…”
Low-dose CBD has a stimulating effect, while high-dose CBD has a sedating effect.
In individuals with insomnia, results suggested that administration of 160 mg/day of CBD increased total sleep time and decreased the frequency of arousals during the night, while low-dose CBD has been associated with increased wakefulness
“CBD efficiently blocked anxiety-induced REM sleep suppression, but had little effect on the alteration of NREM sleep. Conclusively, CBD may block anxiety-induced REM sleep alteration via its anxiolytic effect, rather than via sleep regulation per se.”